Multifaceted roles of STIM proteins
نویسندگان
چکیده
منابع مشابه
STIM and ORAI proteins: crucial roles in hallmarks of cancer.
Intracellular Ca(2+) signals play a central role in several cellular processes; therefore it is not surprising that altered Ca(2+) homeostasis regulatory mechanisms lead to a variety of severe pathologies, including cancer. Stromal interaction molecules (STIM) and ORAI proteins have been identified as critical components of Ca(2+) entry in both store-dependent (SOCE mechanism) and independent b...
متن کاملMultifaceted roles of Furry proteins in invertebrates and vertebrates.
Furry (Fry) is a large protein that is evolutionarily conserved from yeast to human. Fry and its orthologues in invertebrates (termed Tao3p in budding yeast, Mor2p in fission yeast, Sax-2 in nematode and Fry in fruit fly) genetically and physically interact with nuclear Dbf2-related (NDR) kinases (termed Cbk1p in budding yeast, Orb6p in fission yeast, Sax-1 in nematode and Trc in fruitfly), and...
متن کاملThe Multifaceted Roles of Bcl11b in Thymic
The transcription factor Bcl11b is expressed in all T cell subsets and progenitors, starting from the DN2 stage of T cell development, and it regulates critical processes implicated in the development, function, and survival of many of these cells. Among the common roles of Bcl11b in T cell progenitors and mature T cell subsets are the repression of the innate genetic program and, to some exten...
متن کاملThe Multifaceted Biological Roles of Vitamin C
Vitamin C (ascorbic acid) deficiency is known to cause scurvy in humans [1]. Guinea pigs need dietary vitamin C as well and thus historically serve as the only mammalian model for vitamin C studies. Most other species including commonly used animal models, rats and mice, fulfill their need of ascorbic acid by liver synthesis. In the absence of significant intake, mice maintain plasma levels of ...
متن کاملTB domain proteins: evolutionary insights into the multifaceted roles of fibrillins and LTBPs.
Fibrillins and LTBPs [latent TGFβ (transforming growth factor β)-binding proteins] perform vital and complex roles in the extracellular matrix and are relevant to a wide range of human diseases. These proteins share a signature 'eight cysteine' or 'TB (TGFβ-binding protein-like)' domain that is found nowhere else in the human proteome, and which has been shown to mediate a variety of protein-pr...
متن کاملذخیره در منابع من
با ذخیره ی این منبع در منابع من، دسترسی به آن را برای استفاده های بعدی آسان تر کنید
ژورنال
عنوان ژورنال: Pflügers Archiv - European Journal of Physiology
سال: 2013
ISSN: 0031-6768,1432-2013
DOI: 10.1007/s00424-013-1270-8